Section 109(4)(b) in The Drugs and Cosmetics Rules, 1945
(b)in cases where no such test is required or accepted:-(i)if the substance is a serum obtained from a living animal, the earliest date on which any material contributing to the batch was removed from the animal;(ii)if the substance was obtained by the growth of organisms on artificial media, the earliest date on which growth was terminated in any of the material contributing to the batch: