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17. Encyclopedia Britannica (Micropedia), Vol.IV, 1974 Edition, gives the following description of fluorosis:

Fluorosis :--Chronic intoxication with fluorine (usually combined with some other element to form a fluoride) that results in changes in the skeleton and ossification of tendons and ligaments. Exposure to fluoride in optimum amounts (about 1 part per million of fluoride to water) is claimed to be beneficial to the teeth (in the prevention of caries) and probably to bone development; fluorides ingested in very high amounts over a short period are generally poisonous that produce quick death. Mild chronic exposure (6-8 parts per million of fluoride to water) will cause mottling of teeth enamel in children, but the bones are unaffected. In more severe chronic exposure, bone calcium is gradually replaced by fluorine; the bones become soft and crumpled and are chalky white. Protrusions of new bone development in abnormal places. There are few early symptoms when nerves of the spinal cord are compressed. Chronic exposure occurs from air pollution in certain areas, among workers in the insecticide, aluminium-mining, and phosphate and fertiliser industries, and in whole groups of people who live in areas with waters naturally high in fiuorides. The latter form of exposure is not a significant cause to fluorosis in the Western hemisphere, but in parts of India and Arabia. Bone affections are endemic. Treatment is orthopedic; the preferred approach is to prevent the disease by reducing exposure in endangered groups.